Critical Annotated Bibliography Tranexamic Acid Essay

Critical Annotated Bibliography Tranexamic Acid - Essay Example Amandip Singh is also a doctor in the department of anaesthesiology at DMCH. The researchers assert that tranexamic acid significantly decreases blood loss after operation and reduces the need for blood transfusion among students after undergoing total knee replacement (TKR).According to the researchers, Tranexamic acid, which is a synthetic derivative of amino acid lysine, is an effective antifibrinolytic agent. The acid is may reversibly block lysine-binding sites on the plasminogen molecules, thus hinder the formation of plasmin. Other researchers have showed increased use of tranexamic acid in orthopaedic surgery due to its safety, efficacy and low cost. The research was conducted in a tertiary health care facility after obtaining approval from the hospital heath ethics committee with informal consent taken from patients involved in the study. The researchers used randomized double-blinded study involving 40 patients scheduled to undergo unilateral TKR for osteoarthritis. Three s urgeons who had experience in the field to ensure validity of the test conducted the study. The first half of the population was injected with 10mg/kg of tranexamic acid. Conversely, the placebo group underwent the same procedure only that normal saline was used instead of tranexamic acid. ... It was concluded that routine administration of the acid was beneficial to patients undergoing operation. The limitation of the research is that it involved a limited number of populations. Also, the researchers did not monitor the plasminogen levels, D-dimer, thromboelastography, and fibrin degradation products. In addition, the researchers failed to measure hemoglobin levels of transfused blood and weigh sponges, which could have affected the accuracy of calculations. The text did not have sufficient clinical evidence and literature supporting the use of tranexamic acid in preventing preoperative blood loss. The relevance and usefulness of the text to my research is that it informed on the importance of the Tranexamic acid in reducing blood loss during operations in patients. Sekhavat, L., Tabatabaii, A., Dalili, M., Farajkhoda, T., & Tafti, A. (2009). Efficacy of tranexamic acid in reducing blood loss after cesarean section. The Journal Of Maternal-Fetal & Neonatal Medicine. Vol. 22(1), 72-75. The authors of this research journal are medical practitioners at the department of obstetrics and gynecology at Shahod Sehud Hospita, and Health Services, Yard, Iran. They have the ability to produce credible research that can be used in any academic research. The argument presented by the researchers is that cesarean section (CS) rate has been on the increase among women delivering and that CS posse many complications as compared to the normal vaginal birth due to complications related to postpartum bleeding. The medications that have been used to reduce bleeding include prostaglandins, oxytocin, and methylergonovine. The researchers however feel that tranexamic acid, a synthetic derivative of the amino acid lysine that has been applied for several years in the